Abstract
Thiazolidinone is considered as a biologically important active scaffold that possesses almost all types of biological activities. Successful introduction of ralitoline as a potent anti-convulsant, etozoline as a antihypertensive, pioglitazone as a hypoglycemic agent and thiazolidomycin activity against streptomyces species proved potential of thiazolidinone moiety. This diversity in the biological response profile has attracted the attention of many researchers to explore this skeleton to its multiple potential against several activities. This review is complementary to earlier reviews and aims to review the work reported on various biological activities of thiazolidinone derivatives from year 2000 to the beginning of 2011. Data are presented for active compounds, some of which have passed the preclinical testing stage.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Analgesics / chemistry
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Analgesics / pharmacology
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Anticonvulsants / chemistry
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Anticonvulsants / pharmacology
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Antidepressive Agents / chemistry
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Antidepressive Agents / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology
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Antihypertensive Agents / chemistry
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Antihypertensive Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Antitubercular Agents / chemistry
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Antitubercular Agents / pharmacology
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / pharmacology
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Molecular Structure
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Pioglitazone
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Receptor, Muscarinic M1 / agonists
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Streptomyces / drug effects
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Structure-Activity Relationship
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Thiazoles / chemistry
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Thiazoles / pharmacology
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Thiazolidinediones / chemical synthesis
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Thiazolidinediones / chemistry*
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Thiazolidinediones / pharmacology*
Substances
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Analgesics
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Anti-Bacterial Agents
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Anticonvulsants
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Antidepressive Agents
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Antifungal Agents
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Antihypertensive Agents
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Antineoplastic Agents
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Antitubercular Agents
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Hypoglycemic Agents
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Receptor, Muscarinic M1
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Thiazoles
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Thiazolidinediones
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Ralitoline
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etozolin
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Pioglitazone